email page print pageAll Topic Reviews
A New Understanding of Mental Disorders A Theory of Feelings Addictions Memory and the Self"Intimate" Violence against Women1001 Solution-Focused Questions101 Healing Stories101 Things I Wish I'd Known When I Started Using Hypnosis50 Great Myths of Popular Psychology50 Reasons People Give for Believing in a God8 Keys to Body Brain BalanceA Brief History of Modern PsychologyA Conceptual History of PsychologyA Conceptual History of Psychology: Exploring the Tangled Web A Cooperative SpeciesA Guide to Teaching Introductory PsychologyA History of Modern Experimental PsychologyA History of Psychology in AutobiographyA History of Social PsychologyA History of the BrainA History of the MindA Hole in the HeadA Matter of SecurityA Mind of Its OwnA Natural History of Human ThinkingA Place for ConsciousnessA Scientific Search for AltruismA Short Introduction to Promoting Resilience in ChildrenA Social History of PsychologyA Stroll With William JamesA System Architecture Approach to the BrainA Theory of FreedomA Very Bad WizardAbductedAbout FacesAccounts of InnocenceAction, Emotion and WillAdapting MindsAddiction and Self-ControlADHD & MeADHD in AdultsAdieu to GodAdolescence and Body ImageAdult Bipolar DisordersAdvances in Culture and PsychologyAdvances in Identity Theory and ResearchAffect Regulation, Mentalization, and the Development of SelfAffective MappingAgainst EmpathyAgainst HappinessAges and StagesAll Joy and No FunAll Out!All We Have to FearAlterations of ConsciousnessAmerican Psychiatric Publishing Textbook of Neuropsychiatry and Clinical NeurosciencesAn Argument for MindAncient Bodies, Modern LivesAnd BreatheAnimal MadnessAnimal Tool BehaviorAnimals in TranslationAnomalous CognitionAping MankindArtificial ConsciousnessAspects of PsychologismAsperger Syndrome and Your ChildAsperger Syndrome, Adolescence, and IdentityAssessment and Treatment of Childhood Problems, Second EditionAssisted Suicide and the Right to DieAttachedAttention is Cognitive UnisonAutism and the Myth of the Person AloneAutopsy of a Suicidal MindBecoming an Effective PsychotherapistBehavingBehavioral Genetics in the Postgenomic EraBeing No OneBelievingBetween Two WorldsBeyond AppearanceBeyond BlueBeyond BullyingBeyond MadnessBeyond MelancholyBeyond the BrainBeyond the DSM StoryBig DreamsBiofeedback for the BrainBipolar ChildrenBipolar DisorderBipolar KidsBlackwell Handbook of Childhood Cognitive DevelopmentBlind SpotsBlindsight & The Nature of ConsciousnessBlubberlandblueprintBlushBodiesBody ConsciousnessBody Image, Eating Disorders, and Obesity in YouthBody SenseBody WorkBorderline Personality DisorderBorderline Personality Disorder and the Conversational ModelBorn DigitalBorn to Be GoodBorn Together - Reared ApartBounceBoundaries in Human RelationshipsBounded RationalityBowen Theory's SecretsBozo SapiensBrain and CultureBrain and the GazeBrain Arousal and Information TheoryBrain BugsBrain Change TherapyBrain Circuitry and Signaling in PsychiatryBrain FictionBrain, Mind, and Human Behavior in Contemporary Cognitive ScienceBrain-Based Therapy with AdultsBrain-WiseBrainstormBrainstormingBraintrustBrainwashingBrandedBreaking Murphy's LawBright-SidedBuddha's BrainBullying and TeasingBuyologyCan't You Hear Them?CaptureCare of the PsycheCartesian LinguisticsCartographies of the MindCerebrum 2007Cerebrum 2010Cerebrum 2015Cerebrum Anthology 2013Changing the SubjectCharacter Strengths and VirtuesCharacter Strengths InterventionsCheating LessonsChild and Adolescent Psychological DisordersChildren’s Dreaming and the Development of Consciousness Chomsky NotebookClinical Psychiatry in Imperial GermanyClinical Psychology in Practice ClosureCognition and PerceptionCognition and the BrainCognitive BiologyCognitive DissonanceCognitive FictionsCognitive Mechanisms of Belief ChangeCognitive PragmaticsCognitive ScienceCognitive ScienceCognitive Systems and the Extended MindCognitive Therapy of Anxiety DisordersCognitive Unconscious and Human RationalityCold-Blooded KindnessComing of Age in Second LifeCommunication Issues In Autism And Asperger SyndromeCompassion and Healing in Medicine and SocietyComplementary and Alternative Therapies ResearchComprehending ColumbineConfessions of a SociopathConquering Shame and CodependencyConsciousnessConsciousnessConsciousnessConsciousnessConsciousnessConsciousness ConsciousnessConsciousness and Its Place in NatureConsciousness and LanguageConsciousness and Mental LifeConsciousness and MindConsciousness and the NovelConsciousness and the Social BrainConsciousness EmergingConsciousness RecoveredConsciousness RevisitedConsciousness, Self-Consciousness, and the Science of Being HumanConstructing PainConsumer NeuroscienceContemporary Debates in Cognitive ScienceConversations on ConsciousnessConviction of the InnocentCooperation and Its EvolutionCreating a Life of Meaning and CompassionCredit and BlameCritical New Perspectives on Attention Deficit/Hyperactivity DisorderCritical PsychologyCritical Thinking About PsychologyCross-Cultural PsychologyCrowdsourcingCrueltyCultural Assessment in Clinical PsychiatryCuriousDamasio's Error and Descartes' TruthDangerous and Severe Personality DisorderDaniel DennettDaughters of MadnessDeafness In MindDeath and ConsciousnessDeath of a ParentDecomposing the WillDeep Brain StimulationDeep ChinaDefining DifferenceDefining Psychopathology in the 21st CenturyDelusion and Self-DeceptionDelusions of GenderDennett and Ricoeur on the Narrative SelfDeparting from DevianceDescartes' BabyDescartes's Changing MindDescribing Inner Experience?Desert Islands and Other Texts (1953-1974)Destructive EmotionsDevelopment of Geocentric Spatial Language and CognitionDevelopment of PsychopathologyDialogues on DifferenceDid My Neurons Make Me Do It?Digital HemlockDirty MindsDisgust and Its DisordersDisorders of VolitionDo Apes Read Minds?Do Fish Feel Pain?Does Consciousness Cause Behavior?Doing without ConceptsDrunk Tank PinkEducating People to Be Emotionally IntelligentEffective IntentionsEffective Writing in PsychologyEffortless AttentionEmbodied Minds in ActionEmbracing MindEmbracing UncertaintyEMDR Therapy and Somatic PsychologyEmotion and ConsciousnessEmotion ExperienceEmotion RegulationEmotion, Evolution, And RationalityEmotional IntelligenceEmotionally InvolvedEmotionsEmotionsEmotions and LifeEmotions in Humans and ArtifactsEmotions RevealedEmotions, Aggression, and Morality in ChildrenEmotions, Stress, and HealthEmpathyEnjoymentErotic MoralityEscape Your Own PrisonEssays in Social NeuroscienceEssential Sources in the Scientific Study of ConsciousnessEthical Issues in Forensic Mental Health ResearchEthically Challenged ProfessionsEveryday Mind ReadingEvidence for PsiEvidence-Based Mental Health PracticeEvil MenEvolution and Human BehaviorEvolution and LearningEvolution, Games, and GodEvolution, Gender, and RapeEvolutionary Psychology and ViolenceEvolutionary Psychology as Maladapted PsychologyExacting BeautyExperiences of DepressionExperimenterExplaining the BrainExplaining the BrainExplorations in Neuroscience, Psychology and ReligionExploring TranssexualismExpression and the InnerExtending Self-Esteem ResearchExtraordinary BeliefsFact and Value in EmotionFaking ItFatigue as a Window to the BrainFavorite Activities for the Teaching of PsychologyFeeling GoodFeeling Pain and Being in PainFeelings and EmotionsFinding Meaning, Facing FearsFitting In Is OverratedFive Constraints on Predicting BehaviorFlourishingFlow: The Psychology of Optimal ExperienceFolk Psychological NarrativesFooling HoudiniForever YoungFormulation in Psychology and PsychotherapyFoucault, Psychology and the Analytics of PowerFoundational Issues in Human Brain MappingFoundations of Psychological ThoughtFree Will as an Open Scientific ProblemFreedom And NeurobiologyFreedom EvolvesFrom Axons to IdentityFrom Madness to Mental HealthFrom Neurons to Self-ConsciousnessFrom Passions to EmotionsFrom Philosophy to PsychotherapyFrom Symptom to SynapseFrontiers of ConsciousnessGay, Straight, and the Reason WhyGenerosityGenes, Environment, and PsychopathologyGenetic Nature/CultureGeniusGetting Started with EEG NeurofeedbackGetting Under the SkinGlued to GamesGoing SaneGot Parts?Group GeniusGrowing Up GirlGuilt, Shame, and AnxietyGut ReactionsHallucinationHandbook New Sexuality StudiesHandbook of Closeness and IntimacyHandbook of Critical PsychologyHandbook of Emotion RegulationHandbook of EmotionsHandbook of Personality DisordersHandbook of PsychopathyHandbook of Self and IdentityHandbook of Self and IdentityHandbook of Spatial CognitionHappinessHappinessHappinessHappinessHappiness at WorkHappiness Is.Happy at LastHard to GetHardwired BehaviorHatredHealing the SplitHidden ResourcesHope and DespairHot ThoughtHot ThoughtHouse and PsychologyHow Animals Affect UsHow Animals GrieveHow Can the Human Mind Occur in the Physical Universe?How Doctors ThinkHow Enlightenment Changes Your BrainHow Families Still MatterHow History Made the MindHow Infants Know MindsHow Many Friends Does One Person Need?How People ChangeHow Professors ThinkHow The Body Shapes The MindHow the Body Shapes the Way We ThinkHow the Mind Explains BehaviorHow the Mind Uses the BrainHow to Change Someone You LoveHow We ReasonHow We RememberHughes' Outline of Modern PsychiatryHumanHuman BondingHuman Reasoning and Cognitive ScienceHume’s Moral Philosophy and Contemporary PsychologyHypnotismHysteriaiBrainIdentifying Hyperactive ChildrenIdentifying the MindiDisorderImagination and the Meaningful BrainImitation and the Social MindImpulse Control DisordersImpulsivityIn an Unspoken VoiceIn Defense of SentimentalityIn DoubtIn Search of HappinessIn the Wake of 9/11Individual and Collective Memory ConsolidationInner Experience and NeuroscienceInner PresenceInside the American CoupleIntegrated Behavioral Health CareIntegrating Evolution and DevelopmentIntegrating Psychotherapy and PharmacotherapyIntegrity and the Fragile SelfIntellectual DisabilityIntelligenceIntelligence, Destiny, and EducationIntentions and IntentionalityInterdependent MindsInterpreting MindsInto the Minds of MadmenIntoxicating MindsIntrospection VindicatedIntuitionInventing PersonalityInvestigating the Psychological WorldIrrationalityIs There Anything Good About Men?Issues for Families, Schools and CommunitiesJane Sexes It UpJoint AttentionJoint AttentionJudgment and Decision MakingJust a DogJust BabiesJuvenile-Onset SchizophreniaKarl JaspersKey Thinkers in PsychologyKidding OurselvesKids of CharacterKilling MonstersKnowing EmotionsLack of CharacterLanguage OriginsLanguage, Consciousness, CultureLanguage, Vision, and MusicLaw, Mind and BrainLess Than HumanLet Kids Be KidsLet's Talk About DeathLiving NarrativeLiving with Mild Cognitive ImpairmentLonelinessLooking for SpinozaLossLOT 2Love at Goon ParkMachine ConsciousnessMacrocognitionMade for Each OtherMadnessMadness and Modernism: Insanity in the light of modern art, literature, and thought Making a Good Brain GreatMaking Habits, Breaking HabitsMaking Minds and MadnessMaking Up the MindMale SexualityMan and WomanMan's Search for MeaningMan, Beast, and ZombieManic MindsManlinessMapping the MindMarking the MindMarvelous Learning AnimalMasculinity Studies and Feminist TheoryMeaningMeaning, Mortality, and ChoiceMedical MusesMeditating SelflesslyMeetings with a Remarkable ManMemoryMemory and DreamsMemory and EmotionMemory And UnderstandingMental BiologyMental IllnessMental Time TravelMetacognitionMetacognition and Theory of MindMethods in MindMindMindMind and BrainMind and ConsciousnessMind GamesMind Games:Mind in LifeMind TimeMind to MindMind, Brain and the Elusive SoulMindful AngerMindfulnessMindfulnessMindfulness and AcceptanceMindfulness-Based Treatment Approaches: Clinician's Guide to Evidence Base and ApplicationsMinding AnimalsMinding MindsMindreadersMindreading AnimalsMinds, Brains, and LawMindsightMindworldsMirrors in the BrainMistakes Were Made (But Not by Me)Models of MadnessMoodMoral Development and RealityMoral MindsMoral Psychology, Volume 1Moral Psychology, Volume 2Moral Psychology, Volume 3Mothers and OthersMotivation and Cognitive ControlMotivational Interviewing: Preparing People For ChangeMovies and the MindMulticulturalism and the Therapeutic ProcessMultiplicityMuses, Madmen, and ProphetsMy Family AlbumMyths about SuicideNarrative IdentitiesNarrative PsychiatryNarratives in PsychiatryNaturalizing Intention in ActionNature and NarrativeNature Via NurtureNeither Bad nor MadNerveNeurobiology and the Development of Human MoralityNeurochemistry of ConsciousnessNeurodiversityNeuroethicsNeuroLogicNeurological Foundations of Cognitive Neuroscience Neuroscience and PhilosophyNo Child Left DifferentNo Two AlikeNot By Genes AloneNot Much Just Chillin'Not So Abnormal PsychologyNurturing the Older Brain and MindOn AnxietyOn Being an Introvert or Highly Sensitive PersonOn Being HumanOn Being MovedOn Deep History and the BrainOn DesireOn KillingOn Nature and LanguageOn PaedophiliaOn PersonalityOn the Frontier of AdulthoodOn the Origins of Cognitive ScienceOn The Stigma Of Mental IllnessOnflowOpen MindsOpening Skinner's BoxOrigin of MindOrigins of PsychopathologyOther MindsOut of Our HeadsOut of the WoodsOvercoming Depersonalization DisorderPanpsychism and the Religious AttitudePanpsychism in the WestParenting and the Child's WorldPassionate EnginesPathologies of the WestPatient-Based Approaches to Cognitive NeurosciencePediatric PsychopharmacologyPeople Types and Tiger StripesPerception & CognitionPerception beyond InferencePerception, Hallucination, and IllusionPersonal Development and Clinical PsychologyPerspectives on ImitationPhantoms in the BrainPhenomenal Concepts and Phenomenal KnowledgePhenomenology and Philosophy of MindPhilosophical Foundations of NeurosciencePhilosophical MidwiferyPhilosophy and HappinessPhilosophy of PsychologyPhilosophy, Neuroscience and ConsciousnessPhrenologyPhysical RealizationPhysics in MindPieces of LightPlaying with FirePositive PsychologyPositive PsychologyPostcards from the Brain MuseumPostpsychiatryPosttraumatic Stress DisorderPoverty and Brain Development During ChildhoodPractical Ethics for PsychologistsPractical Management of Personality DisorderPractical Management of Personality DisorderPredicative MindsPredictably IrrationalPreference, Belief, and SimilarityPrenatal Testosterone in MindPrivileged AccessProcess-Based CBTProcrastinationPromoting Healthy AttachmentsProust Was a NeuroscientistPsychiatric SlaveryPsychiatry as Cognitive NeurosciencePsychiatry, Psychoanalysis, And The New Biology Of MindPsychological AgencyPsychological Concepts and Biological PsychiatryPsychological Dimensions of the SelfPsychologists Defying the CrowdPsychologyPsychologyPsychology and Consumer CulturePsychology and LawPsychology and the Question of AgencyPsychology for ScreenwritersPsychology of Women: A Handbook of Issues and TheoriesPsychology's GhostsPsychology's Interpretive TurnPsychology's TerritoriesPsychopathologyPsychopathyPsychosis and EmotionPsychotherapy, American Culture, and Social PolicyPutnam CampPutting a Name to ItQuantum Memory PowerQuietRadical DistortionRadical Embodied Cognitive ScienceRadical ExternalismRadical GraceRapeRe-Visioning PsychiatryReal MaterialismReality CheckReconstructing Reason and RepresentationReconstructing the Cognitive WorldRecovery in Mental IllnessRecreative MindsRedirectReducing Adolescent RiskRegulating EmotionsRelational BeingRelational Mental HealthRelational Suicide AssessmentReliability in Cognitive NeuroscienceRemembering HomeRemembering Our ChildhoodResearch Advances in Genetics and GenomicsResearching Children's ExperienceResilience in ChildrenRestoring ResilienceRethinking ADHDRethinking Learning DisabilitiesRethinking Middle YearsRethinking the Western Understanding of the SelfRevolution in PsychologyRoadmap to ResilienceRomance and Sex in Adolescence and Emerging AdulthoodSchadenfreudeSchizophrenia RevealedSchizophrenia, Culture, and SubjectivityScience and Pseudoscience in Clinical PsychologyScience and Pseudoscience in Clinical PsychologySecond NatureSecond NatureSecond That EmotionSecond-order Change in PsychotherapySecrets of the MindSee What I'm SayingSee What I'm SayingSeeing and VisualizingSeeing RedSelf and SocietySelf Comes to MindSelf Control in Society, Mind, and BrainSelf-Awareness Deficits in Psychiatric PatientsSelf-CompassionSelf-Consciousness and 'Split' BrainsSelf-RegulationSelf-Representational Approaches to ConsciousnessSelfless InsightSelvesSerial KillersSex at DawnSex on the BrainSex, Time and PowerSexual Coercion in Primates and HumansSexual DisordersSexual FluiditySexual ReckoningsSexualized BrainsShame and GuiltShatteredSimulating MindsSisyphus's BoulderSleepyheadSNAPSocial NeuroscienceSocial NeuroscienceSocial NeuroscienceSocial Psychology and DiscourseSome We Love, Some We Hate, Some We EatSoul DustSparkSpiral of EntrapmentSplendors and Miseries of the BrainSports Hypnosis in PracticeStanding at Water's EdgeStich and His CriticsStillpowerStop OverreactingStructure and Agency in Everyday LifeStructures of AgencyStuffStumbling on HappinessSubjectivity and SelfhoodSubstance Abuse and EmotionSuicidalSupersizing the MindSweet DreamsSynaptic SelfTales from Both Sides of the BrainTalking Oneself SoberTalking to BabiesTaming the Troublesome ChildTargeting AutismTeaching Problems and the Problems of TeachingTeleological RealismTen Years of Viewing from WithinTestosterone RexThat's DisgustingThe 5 Elements of Effective ThinkingThe Accidental MindThe Age of EmpathyThe Altruism EquationThe Altruistic BrainThe American Psychiatric Publishing Textbook of Clinical PsychiatryThe Anatomy of BiasThe Anxious BrainThe Archaeology of MindThe Art and Science of MindfulnessThe Art InstinctThe Art of HypnosisThe Asymmetrical BrainThe Bifurcation of the SelfThe Big Book of ConceptsThe Big DisconnectThe Birth of IntersubjectivityThe Birth of the MindThe Blackwell Handbook of Organizational Learning and Knowledge ManagementThe Blank SlateThe Body Has a Mind of Its OwnThe Bounds of CognitionThe Boy Who Was Raised as a DogThe BrainThe BrainThe Brain and the Meaning of LifeThe Brain Health BookThe Brain SupremacyThe Brain That Changes ItselfThe Brain's Way of HealingThe Brain: Big Bangs, Behaviors, and BeliefsThe Cambridge Handbook of Cognitive ScienceThe Cambridge Handbook of Situated CognitionThe Character of ConsciousnessThe Chemistry Between UsThe Choice EffectThe Clinical Science of Suicide PreventionThe Cognitive Approach to Conscious MachinesThe Cognitive Behavioral Workbook for Anxiety: A Step-By-Step ProgramThe Cognitive NeurosciencesThe Cognitive-Emotional BrainThe College Fear FactorThe Commercialization of Intimate LifeThe Compass of PleasureThe Compassionate ConnectionThe Concepts of ConsciousnessThe Conscious BrainThe Conscious SelfThe Consuming InstinctThe Creating BrainThe Creative BrainThe Crucible of ConsciousnessThe Crucible of ExperienceThe Cure WithinThe Dao of NeuroscienceThe Developing MindThe Developing MindThe Development of PsychopathologyThe Disappearance of the Social in American Social PsychologyThe Dissolution of MindThe Duty to ProtectThe Educated ParentThe Ego TunnelThe Elephant in the RoomThe Embodied Mind: Cognitive Science and Human ExperienceThe Emotional Foundations of PersonalityThe Emotional Journey of the Alzheimer's FamilyThe Encultured BrainThe Encyclopedia of StupidityThe Enduring Self in People with Alzheimer'sThe Epidemiology of SchizophreniaThe Essential DifferenceThe Ethical BrainThe Evolution of BeautyThe Evolution of ChildhoodThe Evolution of CooperationThe Evolution of LanguageThe Evolution of MindThe Evolving BrainThe Executive BrainThe Faces of TerrorismThe Feeling BrainThe Feeling of What HappensThe First IdeaThe Folly of FoolsThe Folly of FoolsThe Folly of FoolsThe Foundations of Cognitive ArchaeologyThe Fundamentalist MindsetThe GapThe Gender TrapThe Geography of BlissThe Gift of ShynessThe Good LifeThe Good LifeThe Happiness HypothesisThe Happiness of PursuitThe Health Psychology HandbookThe Healthy Aging BrainThe Heart of TraumaThe High Price of MaterialismThe History of PsychologyThe Human FaceThe Human SparkThe Hypomanic EdgeThe Imagery DebateThe Immeasurable MindThe Imprinted BrainThe Incredible Shrinking MindThe Innate MindThe Innate MindThe Integrated SelfThe Intentional BrainThe Language of ThoughtThe Languages of the BrainThe Lexicon of Adlerian PsychologyThe Lie DetectorsThe Lives of the BrainThe Lonely AmericanThe Lust for BloodThe Madness of WomenThe Male BrainThe Man Who Lost His LanguageThe Man Who Shocked the WorldThe Man Who Tasted ShapesThe Man Who Wasn't ThereThe Matter of the MindThe Mature MindThe Mean Girl MotiveThe Meaning of EvilThe Meaning of OthersThe Meaning of the BodyThe Measure of MadnessThe Measure of MindThe Medicalization of Everyday LifeThe Mind and the BrainThe Mind in ContextThe Mind of the ChildThe Mind of the HorseThe Mind's EyeThe Mind, the Body and the WorldThe Mind-Gut ConnectionThe Mindful BrainThe Misleading MindThe Moral MindThe Most Dangerous AnimalThe Most Human HumanThe Mother FactorThe Myth of ChoiceThe Myth of Depression as DiseaseThe Myth of Mirror NeuronsThe Myth of Self HelpThe Myth of Self-EsteemThe Myth of the Spoiled ChildThe Nature of the SelfThe Necessity Of MadnessThe Neuro RevolutionThe Neuron and the MindThe Neuropsychology of the UnconsciousThe Neuroscience of Human RelationshipsThe Neuroscience of PsychotherapyThe Neuroscience of Psychotherapy: Healing the Social BrainThe New BrainThe New Science of DreamingThe New Science of the MindThe New UnconsciousThe Normal PersonalityThe Origins of FairnessThe Overflowing BrainThe Oxford Companion to the MindThe Oxford Handbook of Philosophy of MindThe Paradoxical PrimateThe Perfectionist's HandbookThe Peripheral MindThe Phenomenology ReaderThe Philosopher's Secret FireThe Philosophical BabyThe Political MindThe Politics of HappinessThe Positive Side of Negative EmotionsThe Postnational SelfThe Postpartum EffectThe Power of PlayThe Praeger Handbook of TranssexualityThe Present Moment in Psychotherapy and Everyday LifeThe Primate MindThe Prism of GrammarThe Psychobiology of Trauma and Resilience Across the LifespanThe Psychological Construction of EmotionThe Psychology of Good and EvilThe Psychology of Good and EvilThe Psychology of HappinessThe Psychology of LifestyleThe Psychology of Religious FundamentalismThe Psychology of Science and the Origins of the Scientific MindThe Psychology of Science and the Origins of the Scientific MindThe Psychology of SpiritualityThe Psychology of StereotypingThe Psychology of SuperheroesThe Psychophysiology of Self-AwarenessThe Pursuit of PerfectThe Quest for Mental HealthThe Rational ImaginationThe Ravenous BrainThe Reasons of LoveThe Righteous MindThe Routledge Companion to Philosophy of PsychologyThe Routledge Companion to Philosophy of PsychologyThe Routledge Handbook of ConsciousnessThe Science of EvilThe Science of Intimate RelationshipsThe Science of Shame and its Treatment The Second SelfThe Secret History of EmotionThe Secret Lives of BoysThe Self and Its EmotionsThe Self-Sabotage CycleThe Sense of SelfThe Sensitive SelfThe Shape of ThoughtThe Social AnimalThe Social Nature of Mental IllnessThe Social Neuroscience of EmpathyThe Social Psychology of Good and EvilThe Social Psychology of MoralityThe Social Psychology of MoralityThe Story of Intellectual DisabilityThe Structure of ThinkingThe Survivors ClubThe Talking ApeThe Teenage BrainThe Tell-Tale BrainThe Temperamental ThreadThe Tender CutThe Tending InstinctThe Time ParadoxThe Trauma MythThe Trauma of Psychological TortureThe Trauma of Psychological TortureThe Trouble with IllnessThe True PathThe Truth About GriefThe Turing TestThe Uncertain SciencesThe Undoing ProjectThe Unhappy ChildThe Upside of IrrationalityThe Varieties of ConsciousnessThe War for Children's MindsThe Well-Tuned BrainThe Wild Girl, Natural Man, and the MonsterThe Winner's BrainThe Wisdom in FeelingThe Woman RacketThe World in My Mind, My Mind in the WorldThe Wow ClimaxThe Yipping TigerThemes, Issues and Debates in PsychologyTheoretical Issues in Psychology: An IntroductionTheory of AddictionTheory of MindThings and PlacesThink CatThink Confident, Be ConfidentThinking about AddictionThinking and SeeingThis Emotional Life: In Search of Ourselves...and HappinessThought and LanguageThought in a Hostile WorldTo Have and To Hurt:Toward an Evolutionary Biology of LanguageToward Replacement Parts for the BrainTrauma and Human ExistenceTrauma, Tragedy, TherapyTreating Attachment DisordersTreating Self-InjuryTreating Self-Injury: A Practical GuideTrue to Our FeelingsTrusting the Subject?Understanding and Treating Borderline Personality DisorderUnderstanding ConsciousnessUnderstanding ParanoiaUnderstanding PeopleUnderstanding TerrorismUnderstanding the BrainUndoing Perpetual StressUnlock the Genius WithinUnsettled MindsUnstrange MindsUnthinkingUnthoughtUs and ThemViolent PartnersVirtue, Vice, and PersonalityVision and MindVisual AgnosiaWarrior's DishonourWe Who Are DarkWednesday Is Indigo BlueWelcome to Your BrainWhat Do Women Want?What Dying People WantWhat Have We DoneWhat Intelligence Tests MissWhat Is an Emotion: Classic and Contemporary ReadingsWhat Is Emotion?What is Intelligence?What Is Mental Illness?What Is Thought?What Makes Your Brain Happy and Why You Should Do the Opposite What the Best College Students DoWhat the Dog SawWhat We Know about Emotional IntelligenceWhat We Say MattersWhat's Wrong With Morality?When Boys Become BoysWhen Perfect Isn't Good EnoughWhen the Impossible HappensWhen Walls Become DoorwaysWho's Been Sleeping in Your HeadWho's in Charge?Why Humans Like to CryWhy Love MattersWhy Lyrics LastWhy People CooperateWhy People Die by SuicideWhy Sex Matters: A Darwinian Look at Human BehaviorWhy Smart People Can Be So StupidWhy the Mind is Not a ComputerWhy Us?Why We LieWhy We LoveWhy We SleepWider than the SkyWilliam James at the BoundariesWilling, Wanting, WaitingWittgenstein And PsychologyWomen and Child Sexual AbuseWorking MindsYoga and PsychologyYou Are What You RememberYoung Minds in Social WorldsYour Brain on CubsYour Brain on FoodYour Brain on Food: How Chemicals Control Your Thoughts and Feelings,Your Brain on YogaYour Child in the BalanceZombies and Consciousness
By now, most readers will have been bombarded with the popular and scientific literature on ageing and obesity, sedentary behavior and diabetes, the risks of these to the brain and body. Visits to primary care practitioners for all of us who are ageing is the standard response that we must accept that (1) ageing is inevitable and (2) that decline is inevitable. Clearly from studies such as Snowdon's on the teaching order of the nuns of Notre Dame, this is not necessarily the case even if you accept that (1) is true, which it is.
Your eye will thus be immediately drawn to the chapter headings which include evidence for the fact that cognitive decline at least is not inevitable, nor is it a universal experience anyway, which supports the evidence that it is not built into our genes necessarily. Not news: it may very well be a lifestyle factor. The whole idea is that cognitive reserve can be accumulated by doing the right things, and that preservation of cognitive capacity, i.e. speed and accuracy=efficiency, is a matter of building and maintaining cognitive resilience to physical ageing processes.
The major factors as you will suspect immediately if you read any newspaper health section on paper or on the internet is that of building brain banks of cells by continuing education and new learning, exercise, diet, positive approaches to life and ageing, socializing and the avoidance of loneliness and so on.
Science rather than anecdotal evidence separates out the expert from the charlatan, and it is well accepted that stem cells, and hence neuroprotection and neuroplasticity are a part of ageing brains, and thus can be stimulated via epigenetic systems such as lifestyle interventions. Certain types of mental and physical activity have the capacity, along with food choices, to prolong an efficient cognitive system, even in the face of apparent physical loss of brain tissue, as Snowdon showed with his famous Sister Beatrice.
Both authors are from George Mason University and hence approach the evidence from the basis of their years of academic experience, and the seeming contradictions between cross-sectional vs. longitudinal studies. The authors are quick to let us know that they are looking at healthy ageing vs. pathological ageing, eg. Dementia, but they do make occasional reference to the latter as you must when unable to tease out normal from natural from pathological changes in the brain and therefore cognitive capacity as well.
From the get go, the authors show that perhaps 70-90% of variance in testing scores across time is unrelated to age. That makes sense: people only enter aged care facilities in the most part for health and disability reasons, not their age. Chapter two presents the timescale of emerging research involving amongst other things research into songbirds such as the Zebra Finch, which demonstrated plasticity in response to environmental pressures. This would include preserving sharpness in brains by administering large amounts of nicotine, delaying pathological ageing by reversing changes in the synapses of the brain cells, as one can do with estrogen for instance, or exercise. Whilst cross sectional studies suggest ageing begins in the 30's, longitudinal studies project this decline only in the 60's. Now as we would all agree, I hope, between group studies say little or nothing about the individual, and so do not explain much about the individual trajectory across time nor the individual weighting of lifestyle factors in any one person, as their gene expression is altered by epigenetic factors such as those above.
The downward trend of a group thus may be entirely ignored by a specific individual, whose capacity across time may be highly variable even into the 90's where the trend would predict they are dysfunctional, which they are not, as with Snowdon's nuns or other researchers' songbirds. However, even for songbirds their will come a time when their need to add 1% of their brains each day to produce a new mating song will be overcome by a failure of the brain to be that plastic, making way for the younger male breeding birds to establish their song-bounded territory.
For humans, many of us at advancing age will still however compete with younger individuals on cognitive tasks, especially those with an emotional loading. Wilson, Shupf and others have shown that 25% may show no decline, 15% only slow decline across a few years. These longitudinal studies thus best demonstrate that decline is not universal. Cognition aside, brain volumes may decline, but may also improve in some. Decline in those that do fade are often related to health issues as I mentioned above, as with independence overall. So while the physical aspects of body and brain must decline with age, there are overall indicators that brain and cognitive decline are not inevitable, and may be strongly associated with factors beyond natural ageing.
Pasko Rakic set the world back a long way when he suggested in the 80's that we are born with just about all the neurons we will ever have, which we now know is false. Just as the body of an elderly person responds to resistance training, so does the brain, namely, shifting cognitive weights helps defend against age-related decline. As much as brain volume shrinks in ageing, it does so as children and adolescents go through periods of pruning and arborization, killing of vast amounts of neurons in a process we consider healthy. The loss of grey matter in childhood continues into adulthood in a linear fashion, with losses of grey and white matter from 30 to 90 years old in the vicinity of 14 and 26% respectively, with similar figures for the age bands 22-88 years. Regional changes are also evident as the brain does not shrink uniformly. The prefrontal areas are most vulnerable.
Everyone is in love with MRI technology, but Piguet was able to post-mortem brains from 46-92 and found no grey matter changes, and only white matter decline. So there is a discrepancy between MRI studies in living adults, which shows the grey matter decline first beginning in adolescent children and then onto adults, and autopsy studies (the dead but previously healthy adult) across the span that show this is not the case but show white matter decline instead. Linking grey matter decline to cognitive decline is however proving difficult. Grey matter studies across numerous papers show either weak or even negative correlations with cognitive capacity. If bigger is better in ageing, then Van Petten's study that showed a negative correlation between hippocampal size and memory is confounding, in children and adolescents, with mixed results in older adults. In older adults, Van Petten and colleagues found that prefrontal and temporal gyri sizes were again negatively correlated with good performances. Salat and others again showed that lower grey matter prefrontal volumes were associated with better cognitive performances, not worse. These were cross-sectional designs, with cohort effects depending on what group you are examining.
In longitudinal designs, only the entorhinal cortex, not the prefrontal or hippocampus as such, showed correlations between size and function in memory, as shown by Rodrigue and Raz. This was predictable: the entorhinal area is the one focused on by Alzheimer's researchers, not normal ageing studies.
These findings therefore suggest that regional brain shrinkage with healthy ageing is not associated with overall cognitive decline, although this can happen in apparently healthy older adults in the early stages of as of yet undiagnosed Alzheimer's-related pathology of the entorhinal cortices. The view that most old brains are irreversibly structurally impaired is thus weakened somewhat.
Older people use their brains differently, for instance using bilateral frontal activity as opposed to unilateral in the younger adult. The chapter continues on this vein, analyzing the changes in various cells and structures in the brain, and in the chemistry, e.g. glucose. Ageing effects are thus seen to be selective and subtle in terms of the biophysical properties of the neurons, and only seen in certain regions and for specific cell types. A change in neuron properties does not however necessarily lead to a changes in transmission or cognition. Synaptic changes are not seen unimpaired ageing adults. Chronic disease rather than natural ageing is thus the issue for the 50-60% of adults that do age abnormally in terms of brain function.
The next chapter focusses on ameliorating cognitive ageing, from a neurocognitive framework. Brain plasticity along with cognitive resilience and plasticity of the brain are the focus here, and aligning with most modern views, novel experiences in childhood, physical exercise, which fascinates John Ratey and others is reviewed, diet and nutrition are of course emerging as critical, estrogen and cognition enhancing medication, and learning and cognitive training involving challenging material, all play a role and are discussed. This leads to the next chapters, each of which addresses one of these factors.
Stern's view on cognitive reserve emerges here as it seems that the more one enriches one's education in childhood and early life, the more resilience the brain is in playing the number's game of later cognitive decline. Cognitive enrichment thus leads to cognitive reserve and a firewall against later decline.
Physical exercise evidence such as that from Colcombe and Kramer shows the differential effects of exercise on for instance executive function, spatial or speed capacity. The benefits of exercise on neurogenesis are discussed including the concept of synaptic plasticity and cerebral blood flow. Again, the benefits are discussed in terms of reversing the ageing effects in healthy adults, but not in those with some putative brain condition, despite what some may now say about Alzheimer's etc.
Diet and nutrition, including the effects of caloric restriction are of interest here as well. Changes to insulin sensitivity and body temperature, as well as DNA damage are also reduced by caloric deprivation, which is of small comfort to concentration camp survivors who of course have produced some surprising longevity post-war. Lean muscle mass, prevention of disease, and reduced atrophic changes in subcortical brain areas particularly basal ganglia and insula amongst a host of other benefits are noted in animal studies. More cogently, dietary restriction at the cellular level leads to increased cellular resilience, including resilience to the effects of the SIRT1 gene which has been associated with age related diseases.
It is unlikely though that humans can tolerate fasting alternate days, which may in fact have health risks; most manage however to follow calorie restricted diets. Bayer-Carter and her colleague looked at the role of high fat and high sugar diets, and as others have found, markers for Alzheimer risk were elevated, and in those on low fat and other controlled elements in their diet, cognition improved. Glucose regulation, plasticity, oxidative stress, and other neuroprotective mechanisms are implicated and discussed. Substances such as resveratrol appear to mimic the effects of dietary restriction. Quercetin, found in green tea, has a similar effect. So supplemental diets with red wine and green tea are thought to mitigate many of the effects of not only healthy ageing, but some of the markers for Alzheimer's are reduced, as they are with diets with fat restriction. Fatty acids on the other hand may have overall health benefits, whereas the effect on cognition is equivocal still. Most of us understand that high levels of homocysteine carry risk, and in theory Vit B supplementation should reduce this risk, but the results of supplementation are again equivocal.
If the ageing brain can be reorganized by cognitive demand, as is argued earlier in the book , and if this is dependent on underlying neural plasticity and health, then dietary restriction, resveratrol, and antioxidant foods play a role in keeping an elderly ageing healthy brain at a high level of function. As I have been pushing for years, and integrated approach, using insights from these past chapters, not in isolation, is required (page 126).
The role of estrogen and other cognition-enhancing drugs is then contemplated. Estrogen has both excitatory and neuroprotective and neurogenesis properties amongst other more corporeal effects. Pharmacological agents have been found to be of little value, stimulants such as caffeine more so, and the post-menopausal supplementation of women has to be further examined in respect of other health risks.
Retirement is therefore a double edged sword in terms of the probably loss of cognitive stimulation, and certainly a risk for post-menopausal women. Research in various countries with high versus low retirement age parallels cognitive decline in memory for these groups: use it or lose it applies it seems. The authors conclude here that cognitive training appears to change brain structure and physiology, and neurogenesis my play a role in the benefits of new learning. Training on executive training may be an essential element for training to transfer.
Putting all of the above together across the past chapters, chapter 10 examines the possibility of combinations of the above. Again, the need for an integrated approach is considered beneficial compared to isolated, siloed approaches, the combination of interventions considered much greater than the individual contributions (page 167). The literature on humans is however even smaller than the evidence from animal studies. Nevertheless the implication is clearly on the side of combining various lifestyle interventions to maximize the impact on the ageing brain.
Given the powerful effect of the environment at work and at home on the brain, changing home and work environs to accommodate the limitations of the ageing brain may help, adapting the setting rather than the brain.
No such work would be complete without a discussion of nature versus nurture in producing the ageing phenotype, and chapter 12 does just that, especially in regard to genetic vulnerabilities such as APOE e4 carriers.
So adapting the person via exercise, substituting PU fats for saturated, restriction of calories, learning new skills and acquiring knowledge, using estrogen supplement if female, taking cognitive enhancing medication, looking at lifestyle overall versus integration; also here is the idea of modifying the environment. Most highly valued is substituting fats, regular aerobic exercise, cognitive training, but motivating people here is another issue, especially in terms of diet.
A great first look at integrative approaches to healthy ageing brains, although a more pathology-focused approach would be exciting. However, as integration continues to look for a home, the healthy ageing adult is a great target, especially in terms of institutions such as the Alliance for Ageing Research and their focus both politically and in lifestyle terms. We know that certain of us are more resilient, but does that mean that we were always going to be more resilient and healthy in our choices, or do those choices independently alter anyone and everyone to combat both healthy ageing and abnormal ageing in dementing conditions?
A great resource from these two authors, and I hope we will see the pathology version some time in the future.
© 2012 Roy Sugarman
Roy Sugarman PhD, Director of Applied Neuroscience, Athletes Performance, USA.